We provide cutting edge outcomes research designed to demonstrate the benefit to patients that products and health technologies provide. Our Outcomes Research is applied patient- and population-based research that seeks:
- To study the end results of healthcare in “real life” conditions
- To study healthcare pathways and resource use in the real world
- To study the burden of illness of a specific disease or group of patients
- To target drugs to unmet needs and identify niches
Outcomes Research uses not only medical measures, but also Patient-Reported Outcomes – (PROs) – e.g. Health Related Quality of Life, adherence to treatment, satisfaction with treatment and symptom questionnaires – and other related measures such as utility measurement.
Preferences studies are also included in Outcomes Research. In the last few years, the Patient-Centered Outcomes Research has become more and more important. It helps people and their caregivers communicate and make informed healthcare decisions, allowing their voices to be heard in assessing the value of healthcare options.
For this purpose, we use a series of methods:
- Surveys & Health Services Research
- PROMs development, adaptation and validation
- Utility and preferences assessment
We rely on the resources of our sister company LASER C.R.O. (Cohorts, Registries & Operations) to ensure the optimal collection of clinical data for the conduct of these studies.
Surveys & Health Services Research
Burden of Disease Studies
LASER ANALYTICA has in-depth experience in the conduct of burden of disease studies, both from a patient- and a population- perspective. We combine physician and patient surveys to quantify the burden of illness associated with a specific disease, including estimations of incidence and prevalence, morbidity and mortality outcomes, patient quality of life and also associated economic aspects (e.g. indirect medical costs, non-medical costs…).
Health Services Research
Targeting drugs to patients’ and physicians’ needs, as well as to public health systems, requires a sound knowledge of treatment pathways, patterns of drug use, and health services utilisation. We conduct various types of health services research to inform these decisions, through patient surveys, physician surveys and chart reviews.
Impact on drug and resource use
Benefit-risk management plans often rely on the evaluation of the use of drugs and of health technologies. So-called ‘risk sharing agreements’ and ‘managed entry schemes’ often entail the commitment by industry to assess the actual use of resources after launch, in the real life practice.
LASER ANALYTICA has extensive experience in conductung impact studies with direct contact and follow-up of patients by telephone interviews. When necessary, the operational services of LASER C.R.O. are utilized to conduct these studies (however, other resources and external CROs may be used as well)
To get a complete appreciation of the unmet/uncovered needs of patients with a particular disease, to define the most important needs, the best market access roads and the commonalities and differences between groups, we also use qualitative research methods like focus groups, Delphi panels and semi-structured interviews in addition to surveys. We use CAQDAS programs (“Computer Assisted Qualitative Data Analysis Systems”) to improve the processes of storage, organization, analysis and presentation of qualitative data.
Patient-Reported Outcome Measures
LASER ANALYTICA helps customers choose the best tools for their needs (HRQoL, satisfaction with treatment, adherence or symptom measures) and to solve any problems or questions related to these instruments. We perform cultural adaptations of PROs across different countries and we design and carry out validation studies to assess their psychometric properties (reliability, validity and sensitivity to change). To address diseases for which there are no available robust tools to use, we offer to develop a new one.
We apply Classic Theory, Rasch Model and Item Response Theory (IRT) in developing and validating PROs. Moreover, we have experience in developing Computer Adaptive Test (CAT) based on IRT.
|Patient-Reported Outcome Measures & Quality of Life||
Utility measurement & preferences studies
We also carry out observational studies to discover patients’ preferences about different treatment alternatives, allowing the voice of patients to be heard in assessing the value of healthcare options.
LASER ANALYTICA applies classic quantitative methods in preference elicitation games: ranking, rating and choice- based methods, using Conjoint Analysis, Standard Gamble, Time Trade-off or willingness to pay. We also use our deep understanding of qualitative methodology to study patient preferences in order to include the patient’s point of view in assessing the value of new products. Another application of our knowledge on preference elicitation is the valuation of disease-specific health states in order to obtain specific utility measurements to be included in health economic analysis.